Toxocara canis (also known as dog roundworm) is worldwide distributed helminth parasite of dogs and other canids. T. canis are gonochorists, adult worms measure from 9 to 18 cm, are yellow-white in color, and occur in the intestine of the definitive host. In adult dogs, the infection is usually asymptomatic. By contrast, massive infection with T. canis can be fatal in puppies. As paratenic hosts, a number of various vertebrates, including humans, and some invertebrates can become infected. Humans are infected, like other paratenic hosts, by ingestion of embryonated T. canis eggs. The disease caused by migrating T. canis larvae (toxocariasis) results in two syndromes: visceralis larva migrans and ocularis larva migrans. Owing to transmission of the infection from bitches to puppies, preventive anthelmintic treatment of newborn puppies is strongly recommended. Several antihelmintic drugs are effective against adult worms, for example pyrantel, fenbendazole, selamectine etc.
There are four modes of infection associated with this species. The basic form is typical to all ascaroides, the egg containing the L2(the second larval developmental stage), being infective, at optimal temperature and humidity, four weeks after secreted in the faeces to the environment. After ingestion, and hatching in the small intestine, the L2 travel through the portal blood stream into the liver and lungs. Such migratory route is known as entero-hepatic-pulmonar larval migration. The second molt takes place in the lungs, the now L3 returns via the trachea and into the intestines where the final two molts take place. This form of infection occurs regularly only in dogs of up to three months of age. In older dogs, this type of migration occurs less frequently and at six months it is almost ceased. Instead, the L2 travel to a wide range of organs including the liver, lungs, brain, heart and skeletal muscles, as well as to the walls of the gastrointestinal tract. In pregnant bitches prenatal infection can occur, where larvae become mobilized (at approximately three weeks prior to parturition) and migrate to the lungs of the foetus, here molting into L3 just prior to birth. In the newborn pup the cycle is completed when the larva migrates through the trachea and into the intestinal lumen, where the final molts take place. Once infected, a bitch will usually harbor sufficient larvae to subsequently infect all of her litters, even if she never again encounters an infection. A certain amount of the bitch's dormant larvae penetrate into the intestinal lumen, where molting into adulthood take, yet again, place, thus leading to a new release of eggs containing L1 larvae. The suckling pup may be infected by the presence of L3 in the milk during the first three weeks of lactation. There is no migration in the pup via this route. L2 may also be ingested by a variety of animals where it stays in a dormant stage inside the animals tissue until the intermediate host has been eaten by a dog, when subsequent development is confined to the gastrointestinal tract.
A 2003 study found that humans can be infected by this roundworm, a condition called toxocarosis, just by stroking an infected dog's fur. In humans, this parasite usually grows in the back of the eye, which can result in blindness, or in the liver or lungs. However, a 2004 study showed that, of 15 infected dogs, only 7 had eggs in their coat, and that no more than one egg was found on each dog. Furthermore, only 4% of those eggs were infectious. Given the low concentration of fertile eggs on infected dogs' coats (less than 0.00186% per gram), it is plausible that such eggs were transferred to the dog's coat by contact with fecal deposites in the environment, making dog coats be passive transport hosts. The risk of being infected by petting a dog is extremely limited and, since a single infected puppy can produce more than 100,000 roundworm eggs per gram of feces, humans are much more likely to be infected by contact with feces than contact with fur. As such, there is little reason for humans to fear infection as long as basic hygiene, like hand-washing, is followed. There are several treatments, all of which are cheap and easily-accessible by the average dog owner, than can prevent a dog from becoming infected or rid an infected pet of its roundworm parasites.
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